For a much more comprehensive list see Awesome Python Applications.
- Airflow – Apache, workflow automation.
- ajenti
- ansible – IT automation.
- autosploit
- azure-cli
- cactus
- calibre
- certbot
- django-cms
- docker
- erpnext
- fabric
- fail2ban
- flaskbb
- gam
- gitsome
- home-assistant
- httpbin
- hypothesis
- jupyter
- letsencrypt
- mozdef
- pelican
- plone
- psutil
- Redash – Connect and query data.
- salt
- saws
- sentry
- Snipe-IT Open Source IT Asset Management Software.
- Superset – Apache, BI.
- supervisor
- wagtail